Cao, Rong, Ph.D.
Research ScientistContact Information:
93 Stone Road West
Guelph, Ontario N1G 5C9
Telephone: 226-217-8108
Fax: 519-829-2600
Email: rong.cao@agr.gc.ca
Areas of Expertise:
- characterization and utilization of antioxidative and bioactive phytochemicals in important Canadian crops and native plants for improved human health and food safety and quality
- agri-food by-products and explore their potential as source of nutraceutical and functional food ingredients
- bioavailability, metabolism and mode of action of phytochemical antioxidants
- phytochemicals with antimicrobial activities.
Current Projects:
- Development of natural patulin decontamination methods and value-added products from apple and apple pomace for human consumption
- Discovery, characterization and production of bioactive phytochemicals for nutraceutical, functional food and non-food applications
- Rural technology development and characterization of bioactive phytochemicals for nutraceutical or functional food applications
Affiliations:
- Special Graduate Faculty, Department of Food Sciences, University of Guelph
- Special Graduate Faculty, Department of Human Biology and Nutrition, University of Guelph
- Special Graduate Faculty, Department of Plant Agriculture, University of Guelph
- Adjunct Professor, Baicheng Agricultural Research Institute, China
Research Publications:
The links below lead to abstracts with access to full text.2013:
- Li, H., Deng, Z.-Y., Liu, R., Loewen, S., and Tsao, R. (2013). "Carotenoid compositions of coloured tomato cultivars and contribution to antioxidant activities and protection against H2O2-induced cell death in H9c2.", Food Chemistry, 136(2), pp. 878-888. doi : 10.1016/j.foodchem.2012.08.020
- Wu, T., McCallum, J.L., Wang, S., Liu, R., Zhu, H., and Tsao, R. (2013). "Evaluation of antioxidant activities and chemical characterisation of staghorn sumac fruit (Rhus hirta L.).", Food Chemistry, 138(2), pp. 1333-1340. doi : 10.1016/j.foodchem.2012.10.086
2012:
- Hu, C., Tsao, R., Liu, R., Sullivan, J.A., and McDonald, M.R. (2012). "Influence of cultivar and year on phytochemical and antioxidant activity of potato (Solanum tuberosum L.) in Ontario.", Canadian Journal of Plant Science, 92(3), pp. 485-493. doi : 10.4141/CJPS2011-212
- Li, H., Deng, Z.-Y., Liu, R., Loewen, S., and Tsao, R. (2012). "Ultra-performance liquid chromatographic separation of geometric isomers of carotenoids and antioxidant activities of 20 tomato cultivars and breeding lines.", Food Chemistry, 132(1), pp. 508-517. doi : 10.1016/j.foodchem.2011.10.017
- Li, H., Deng, Z.-Y., Wu, T., Liu, R., Loewen, S., and Tsao, R. (2012). "Microwave-assisted extraction of phenolics with maximal antioxidant activities in tomatoes.", Food Chemistry, 130(4), pp. 928-936. doi : 10.1016/j.foodchem.2011.08.019
- Li, H., Deng, Z.-Y., Zhu, H., Hu, C., Liu, R., Young, J.C., and Tsao, R. (2012). "Highly pigmented vegetables: Anthocyanin compositions and their role in antioxidant activities.", Food Research International, 46(1), pp. 250-259. doi : 10.1016/j.foodres.2011.12.014
- Li, N., Tsao, R., Sui, Z., Ma, J., Liu, Z.-Q., and Liu, Z.Y. (2012). "Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model.", Planta Medica, 78(7), pp. 692-697. doi : 10.1055/s-0031-1298368
- Meca, G., Luciano, F.B., Zhou, T., Tsao, R., and Mañes, J. (2012). "Chemical reduction of the mycotoxin beauvericin using allyl isothiocyanate.", Food and Chemical Toxicology, 50(5), pp. 1755-1762. doi : 10.1016/j.fct.2012.02.070
- Plank, D.W., Szpylka, J., Sapirstein, H.D., Woollard, D., Zapf, C.M., Lee, V., Chen, C.-Y.O., Liu, R.H., Tsao, R., Düsterloh, A., and Baugh, S. (2012). "Determination of antioxidant activity in foods and beverages by reaction with 2,2'-Diphenyl-1-Picrylhydrazyl (DPPH): Collaborative study first action 2012.04.", Journal of AOAC International, 95(6), pp. 1562-1569. doi : 10.5740/jaoacint.CS2012_04
- Sessa, M., Casazza, A.A., Perego, P., Tsao, R., Ferrari, G., and Donsì, F. (2012). "Exploitation of Polyphenolic Extracts from Grape Marc as Natural Antioxidants by Encapsulation in Lipid-Based Nanodelivery Systems.", Food and Bioprocess Technology. doi : 10.1007/s11947-012-0911-9
- Stoffyn, O. M., Tsao, R., Liu, R., and Wolyn, D.J. (2012). "The effects of environment and storage on rutin concentration in two asparagus cultivars grown in southern Ontario.", Canadian Journal of Plant Science, 92(5), pp. 901-912. doi : 10.4141/cjps2012-022
- Wang, S., Meckling, K.A., Marcone, M.F., Kakuda, Y., Proulx, A.K., and Tsao, R. (2012). "In vitro antioxidant synergism and antagonism between food extracts can lead to similar activities in H2O2-induced cell death, caspase-3 and MMP-2 activities in H9c2 cells.", Journal of the Science of Food and Agriculture, 92(15), pp. 2983-2993. doi : 10.1002/jsfa.5711
- Wu, T., Yan, J., Liu, R., Marcone, M.F., Aisa, H.A., and Tsao, R. (2012). "Optimization of microwave-assisted extraction of phenolics from potato and its downstream waste using orthogonal array design.", Food Chemistry, 133(4), pp. 1292-1298. doi : 10.1016/j.foodchem.2011.08.002
2011:
- Gui, Y., Tsao, R., Li, L., Liu, C.M., Wang, J., and Zong, X. (2011). "Preparative separation of chromones in plant extract of Saposhnikovia divaricata by high-performance counter-current chromatography.", Journal of Separation Science, 34(5), pp. 520-526. doi : 10.1002/jssc.201000721
- Li, D., Charles, M.T., Carisse, O., Tsao, R., Dubé, C., and Khanizadeh, S. (2011). "Changes in ascorbate-glutathione pathway enzymes in response to Mycosphaerella fragariae infection in selected strawberry genotypes.", Archives of Phytopathology and Plant Protection, 44(8), pp. 712-725. doi : 10.1080/03235400903266297
- Li, H., Deng, Z.-Y., Liu, R., Young, J.C., Zhu, H., Loewen, S., and Tsao, R. (2011). "Characterization of phytochemicals and antioxidant activities of a purple tomato (Solanum lycopersicum L.).", Journal of Agricultural and Food Chemistry, 59(21), pp. 11803-11811. doi : 10.1021/jf202364v
- Sessa, M., Tsao, R., Liu, R., Ferrari, G., and Donsì, F. (2011). "Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during in Vitro Digestion.", Journal of Agricultural and Food Chemistry, 59(23), pp. 12352-12360. doi : 10.1021/jf2031346
- Shao, S., Duncan, A.M., Yang, R., Marcone, M.F., Rajcan, I., and Tsao, R. (2011). "Systematic evaluation of pre-HPLC sample processing methods on total and individual isoflavones in soybeans and soy products.", Food Research International, 44(8), pp. 2425-2434. doi : 10.1016/j.foodres.2010.12.041
- Soliman, S.S.M., Tsao, R., and Raizada, M.N. (2011). "Chemical Inhibitors Suggest Endophytic Fungal Paclitaxel Is Derived from Both Mevalonate and Non-mevalonate-like Pathways.", Journal of Natural Products, 74(12), pp. 2497-2504. doi : 10.1021/np200303v
- Wang, S., Meckling, K.A., Marcone, M.F., Kakuda, Y., and Tsao, R. (2011). "Can phytochemical antioxidant rich foods act as anti-cancer agents?", Food Research International, 44(9), pp. 2545-2554. doi : 10.1016/j.foodres.2011.05.021
- Wang, S., Meckling, K.A., Marcone, M.F., Kakuda, Y., and Tsao, R. (2011). "Synergistic, additive, and antagonistic effects of food mixtures on total antioxidant capacities.", Journal of Agricultural and Food Chemistry, 59(3), pp. 960-968. doi : 10.1021/jf1040977
- Wang, S., Melnyk, J.P., Tsao, R., and Marcone, M.F. (2011). "How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health.", Food Research International, 44(1), pp. 14-22. doi : 10.1016/j.foodres.2010.09.028
- Yang, R., Hanwell, H., Zhang, J., Tsao, R., and Meckling, K.A. (2011). "Antiproliferative Activity of Pomiferin in Normal (MCF-10A) and Transformed (MCF-7) Breast Epithelial Cells.", Journal of Agricultural and Food Chemistry, 59(24), pp. 13328-13336. doi : 10.1021/jf202898g
- Yu, C., Ranieri, M., Lv, D., Zhang, M., Charles, M.T., Tsao, R., Rékika, D., Kempler, C., and Khanizadeh, S. (2011). "Phenolic Composition and Antioxidant Capacity of Newly Developed Strawberry Lines from British Columbia and Quebec.", International Journal of Food Properties, 14(1), pp. 59-67. doi : 10.1080/10942910903131415
2010:
- Chu, C.-L., Young, J.C., and Tsao, R. (2010). "Effect of controlled atmosphere storage on internal ethylene, alpha-farnesene, total esters, and total phenolic concentrations of apples.", Acta Horticulturae (ISHS), 857, pp. 89-96.
- Khanizadeh, S., Deschênes, M., Dubé, C., Tsao, R., Gauthier, L., and Gosselin, A. (2010). "‘Jeanne d'Orléans’ Red Raspberry.", HortScience, 45(8), pp. 1283-1285.
- Shao, S., Hernandez, M., Kramer, J.K.G., Rinker, D.L., and Tsao, R. (2010). "Ergosterol profiles, fatty acid composition, and antioxidant activities of button mushrooms as affected by tissue part and developmental stage.", Journal of Agricultural and Food Chemistry, 58(22), pp. 11616-11625. doi : 10.1021/jf102285b
- Tao, S., Zhang, S., Tsao, R., Charles, M.T., Yang, R., and Khanizadeh, S. (2010). "In vitro antifungal activity and mode of action of selected polyphenolic antioxidants on Botrytis cinerea.", Archives of Phytopathology and Plant Protection, 43(16), pp. 1564-1578. doi : 10.1080/03235400802583834
- Tsao, R. (2010). "Chemistry and Biochemistry of Dietary Polyphenols (Review).", Nutrients, 2(12), pp. 1231-1246. doi : 10.3390/nu2121231
- Wang, Q., Tury, E., Rékika, D., Charles, M.T., Tsao, R., Hao, Y.-J., Dubé, C., and Khanizadeh, S. (2010). "Agronomic Characteristics and Chemical Composition of Newly Developed Day-Neutral Strawberry Lines by Agriculture and Agri-Food Canada.", International Journal of Food Properties, 13(6), pp. 1234-1243. doi : 10.1080/10942910903013415
- Yu, H., Zhou, T., Gong, J., Young, J.C., Su, X., Li, X.-Z., Zhu, H., Tsao, R., and Yang, R. (2010). "Isolation of deoxynivalenol-transforming bacteria from the chicken intestines using approach of PCR-DGGE guided microbial selection.", BMC Bioinformatics, 10:182. doi : 10.1186/1471-2180-10-182
2009:
- He, J., Tsao, R., Yang, R., and Zhou, T. (2009). "Purification of patulin from Penicillium expansum culture: high-speed counter-current chromatography (HSCCC) versus preparative high-performance liquid chromatography (prep-HPLC).", Food Additives and Contaminants, Part A, 26(1), pp. 101-107. doi : 10.1080/02652030802273148
- Jiang, G., Jiang, Y., Yang, B., Yu, C.Y., Tsao, R., Zhang, H., and Chen, F. (2009). "Structural characteristics and antioxidant activities of oligosaccharides from longan fruit pericarp.", Journal of Agricultural and Food Chemistry, 57(19), pp. 9293-9298. doi : 10.1021/jf902534v
- Khanizadeh, S., Deschênes, M., Levasseur, A., Carisse, O., Charles, M.T., Rékika, D., Gauthier, L., Gosselin, A., Tsao, R., Yang, R., DeEll, J.R., and Sullivan, J.A. (2009). "‘St-Jean d’Orléans’ Strawberry.", Acta Horticulturae (ISHS), 814, pp. 275-276.
- Khanizadeh, S., Ding, L., Tsao, R., Rékika, D., Yang, R., Charles, M.T., and Rupasinghe, H.P.V. (2009). "Phytochemical profile of Selected Processing Apple Genotypes.", Acta Horticulturae (ISHS), 814, pp. 545-550.
- Khanizadeh, S., Groleau, Y., Levasseur, A., Charles, M.T., Tsao, R., Yang, R., DeEll, J.R., and Toivonen, P.M.A. (2009). "Eden™ a non Browning apple suitable for fresh cut slice and fruit Salad.", Acta Horticulturae (ISHS), 814, pp. 273-274.
- Khanizadeh, S., Groleau, Y., Tsao, R., Yang, R., Alli, I., Prange, R.K., and Demoy, R. (2009). "‘Diva’ Apple.", HortScience, 44(5), pp. 1478-1480.
- Khanizadeh, S., Rékika, D., Ehsani-Moghaddam, B., Tsao, R., Yang, R., Charles, M.T., Sullivan, J.A., Gauthier, L., Gosselin, A., Potel, A.-M., Reynaud, G., and Thomas, É. (2009). "Horticultural Characteristics and Chemical Composition of Advanced Raspberry Lines from Quebec and Ontario.", Food Science and Technology / Lebensmittel-Wissenschaft und-Technologie (LWT), 42(4), pp. 893-898. doi : 10.1016/j.lwt.2008.08.016
- Khanizadeh, S., Tao, S., Zhang, S., Tsao, R., Rékika, D., Yang, R., Charles, M.T., Gauthier, L., and Gosselin, A. (2009). "Profile of antioxidant activities of selected strawberry genotypes.", Acta Horticulturae (ISHS), 814, pp. 551-556.
- Khanizadeh, S., Tsao, R., Rékika, D., Yang, R., Charles, M.T., and Rupasinghe, H.P.V. (2009). "Advances in Fruit Breeding In Eastern Canada - Role of Phytochemicals in Designing Specialty Fruits.", Acta Horticulturae (ISHS), 814, pp. 205-208.
- Li, H., Song, F., Xing, J., Tsao, R., Liu, Z.-Q., and Liu, S.-Y. (2009). "Screening and Structural Characterization of α-Glucosidase Inhibitors from Hawthorn Leaf Flavonoids Extract by Ultrafiltration LC-DAD-MSn and SORI-CID FTICR MS.", Journal of the American Society for Mass Spectrometry, 20(8), pp. 1496-1503. doi : 10.1016/j.jasms.2009.04.003
- Li, L., Liu, C.-M., Liu, Z.-Q., Tsao, R., and Liu, S.-Y. (2009). "Identification of Phenylethanoid Glycosides in Plant Extract of Plantago asiatica L. by Liquid Chromatography-Electrospray Ionization Mass Spectrometry.", Chinese Journal of Chemistry, 27(3), pp. 541-545. doi : 10.1002/cjoc.200990088
- McCallum, J.L., Fisher, H., Strommer, J.N., and Tsao, R. (2009). "Effect of Terroir on Anthocyanins of Vitis vinifera L. Varieties Cabernet Sauvignon and Cabernet Franc Grown in Different Niagara Appellations.", Acta Horticulturae (ISHS), 827, pp. 287-299.
- Petit, H.V., Gagnon, N., Mir, P.S., Tsao, R., and Cui, S.W. (2009). "Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal.", Journal of Dairy Research, 76(3), pp. 257-264. doi : 10.1017/S0022029909003999
- Shao, S., Duncan, A.M., Yang, R., Marcone, M.F., Rajcan, I., and Tsao, R. (2009). "Tracking isoflavones: From soybean to soy flour, soy protein isolates to functional soy bread.", Journal of Functional Foods, 1(1), pp. 119-127. doi : 10.1016/j.jff.2008.09.013
- Tsao, R. (2009). "Phytochemical Profiles of Potato and their Role in Human Health and Wellness.", Food, 3(Spec. Issue 1), pp. 125-135.
Other Science Related Publications:
2012:
- Chen, P.X., Tsao, R., Liu, R., Marcone, M.F., and Pauls, K.P. (2012). "Polyphenolic profile of common dry beans (Phaseolus vulgaris L.).", Canadian Institute of Food Science and Technology, Canada, May 2012. (Presentation)
- Ma, J., Zhou, T., Warriner, K., Fernando, W.G.D., and Tsao, R. (2012). "Can mustard meal make food labels “green”.", 10th Annual OMAFRA Food Safety Research Forum, Guelph, ON, Canada, May 2, 2012. (Poster)
- Ma, J., Zhou, T., Warriner, K., and Tsao, R. (2012). "Allyl isothiocynate derived from oriental defatted mustard meal as a natural antimicrobial to inhibit the growth of moulds on bread.", 50th National Conference of the Canadian Institute of Food Science and Technology (CIFST's): Innovation meets Commercialization, Niagara Falls, ON, Canada, May 27-29, 2012. (Poster)
- Navabi, A., Pauls, K.P., Yu, K., Tsao, R., Woodrow, L., and Poysa, V. (2012). "A Multi- Disciplinary Approach Towards Developing Bean Varieties for Sustainable Dry Bean Production in Ontario. Research Update.", Pulse Science Cluster Scientific Meeting, Niagara Falls Marriott Gateway, Niagara Falls, ON, Canada, November 6, 2012.
- Navabi, A., Pauls, K.P., Yu, K., Tsao, R., Woodrow, L., and Poysa, V. (2012). "A Multi- Disciplinary Approach Towards Developing Bean Varieties for Sustainable Dry Bean Production in Ontario.", Pulse Science Cluster Scientific Meeting, Saskatoon, SK, Canada, November 17-18, 2011.
- Perry, G.E., Crosby, W.L., Yu, K., Navabi, A., Zou, X., Power, K.A., Marsolais, F., Xie, W., Weersink, A., Tsao, R., Cooper, D., and Pauls, K.P. (2012). "Sequencing the bean genome: Using comparative genomics to examine interspecific introgressions.", Canadian Society of Plant Biologists Meeting (CSPB 2012), University of Alberta Campus, Edmonton, AB, Canada, June 25-27, 2012. (Presentation)
- Power, K.A., Villeneuve, S., Mondor, M., Fustier, P., Arcand, Y., Lamarche, F., Britten, M., Cui, S.W., Tsao, R., Fofana, B., and Wanasundara, P.K.J.P.D. (2012). "Recent progress on the incorporation of flaxseed into cereal based matrices: delivery of bioactives to target sites and a comprehensive assessment of their biological effects.", 64th Flax Institute of the United States, Doublewood Inn, Fargo, ND, USA, March 29-30, 2012. (Presentation)
- Song, J., Tsao, R., Yang, R., and Campbell-Palmer, L. (2012). "Effect of 1-MCP treatment on polyphenolics and antioxidants compounds in apple fruit during ripening.", 109th Annual Conference of the American Society for Horticultural Science (ASHS), InterContinental Miami Hotel, Miami, FL, USA, July 31-August 3, 2012, Published in: HortScience 47(9), S264. (Abstract)
- Zhang, C., Lu, J., Zarepoor, L., Tsao, R., and Power, K.A. (2012). "Common Beans Induce both Beneficial and Adverse Effects on Colitis Symptoms in Mice.", 9th Canadian Pulse Research Workshop, Niagara Falls Marriott Gateway, Niagara Falls, ON, Canada, November 6-12, 2012.
- Zhang, C., Lu, J., Zarepoor, L., Tsao, R., and Power, K.A. (2012). "Power Common Beans Induce both Beneficial and Adverse Effects on Colitis Symptoms in Mice.", 9th Canadian Pulse Research Workshop, Niagara Falls Marriott Gateway, Niagara Falls, ON, Canada, November 6-12, 2012.
- Zhang, C., Zarepoor, L., Lu, J., Da, C.R., Wu, W., Tsao, R., Pauls, K.P., and Power, K.A. (2012). "Bean health benefits depends on timing of consumption.", Ontario Ministry of Agriculture Food and Rural Affairs (OMAFRA) Food for Health Meeting, Guelph, ON, Canada, June 2012. (Poster)
2011:
- Ma, J., Zhou, T., Warriner, K., Tsao, R., and Fernando, W.G.D. (2011). "Suppressing penicillium spp. by gaseous Allyl isothiocynate from oriental mustard meal.", 9th Annual OMAFRA Food Safety Research Forum, Guelph, ON, Canada, May 5, 2011. (Poster)
- Perry, G.E., Crosby, W., Shi, C., Power, K.A., Marsolais, F., Xie, W., Weersink, A., Tsao, R., Cooper, D.M., and Pauls, K.P. (2011). "Sequencing the bean genome: the applied bean genomics and bioproducts project.", Plant Canada 2011, Saint Mary’s University, Halifax, NS, Canada, July 17-21, 2011. (Poster)
- Perry, G.E., Crosby, W., Yu, K., Shi, C., Powers, K., Marsolais, F., Xie, W., Weersink, A., Tsao, R., Siddiqua, M., Cooper, D.M., and Pauls, K.P. (2011). "The applied bean genomics and bioproducts project: sequencing the bean genome.", Biennial Meeting of the Bean Improvement Cooperative and North American Pulse Improvement Association (BIC/NAPIA 2011), Verdanza Hotel, San Juan, Puerto Rico, October 30-November 2, 2011.
2010:
- Lu, L., Song, F.-R., Tsao, R., Liu, Z.-Q., and Liu, S.-Y. (2010). "Studies on the homolytic and heterolytic cleavage of kaempferol and kaempferide glycosides using electrospray ionization tandem mass spectrometry (Letter to the Editor).", Rapid Communications in Mass Spectrometry (RCM), 24(1), pp. 169-172.
- Proulx, A.K. and Tsao, R. (2010). "When Antioxidants Aren’t Antioxidants: Mixed results from soy hydrolysates when evaluated by wet chemistry and shelf-life antioxidant model systems.", 2010 Canadian Institute of Food Science & Technology (CIFST) and AAFC Conference, Fairmont Winnipeg Hotel, Winnipeg, MB, Canada, May 30-June 1, 2010, # 06-5. (Abstract)
- Tsao, R. (2010). "Prenylated flavonoids: antioxidant, anti-cancer activities and bioavailability.", 2010 Canadian Institute of Food Science & Technology (CIFST) and AAFC Conference, Fairmont Winnipeg Hotel, Winnipeg, MB, Canada, May 30-June 1, 2010, # 07-4. (Abstract)
2009:
- McCallum, J.L. and Tsao, R. (2009). "Chemistry of flavonoids.", in de la Rosa, L.A., Alvarez-Parrilla, E., and Gonzalez-Aguilar, G.A. (eds.) - Fruit and Vegetable Phytochemicals: Chemistry, nutritional value, stability, Wiley - Blackwell, Chapter 5, pp. 131-154.
- Proulx, A.K. and Tsao, R. (2009). "Towards identifying the chemical mechanisms of non-enzymatic peptide antioxidants (Abstract #46).", 2009 Annual Meeting of the International Society for Nutraceuticals and Functional Foods (ISNFF), Golden Gate Holiday Inn, San Francisco, CA, USA, November 1-4, 2009. (Abstract)
- Tsao, R. (2009). "Prenylated flavonoids: antioxidant, anti-cancer activities and bioavailability.", 2009 Annual Meeting of the International Society for Nutraceuticals and Functional Foods (ISNFF), Golden Gate Holiday Inn, San Francisco, CA, USA, November 1-4, 2009, #104. (Abstract)
- Tsao, R. and Li, L. (2009). "Phytochemical profiles and potential health benefits of heartnut (Juglans ailanthifolia var. cordiformis): A comparison with common walnut (Juglans regia L.).", in Alasalvar, C. and Shahidi, F. (eds.) - Tree Nuts: Composition, Phytochemicals, and Health Effects, CRC Press Taylor & Francis, Chapter 14, pp. 237-247.