Wang, Aiming, Ph.D.
Research ScientistContact Information:
1391 Sandford St
London, Ontario N5V 4T3
Telephone: 519-457-1470 (313)
Fax: 519-457-3997
Email: aiming.wang@agr.gc.ca
Areas of Expertise:
- Understanding of molecular virus-plant interactions and virus genome expression and replication mechanism
- Molecular isolation of host factors and natural resistance genes
- Development of novel antiviral strategies through biotechnology
- Beneficial uses of plant viruses
Current Projects:
- Development of genetic resistance to Plum pox virus in Prunus for the eradication of Plum pox virus in Canada
- Development of a Soybean mosaic virus-based vector for functional genomics and molecular farming in legume plants
- Molecular characterization of Soybean mosaic virus (SMV) in Ontario and evaluation of genetic resistance to SMV in the Soybean varieties grown in Ontario
Affiliations:
- Adjunct Professor, Department of Biology, University of Western Ontario
- Lifetime Member, American Society for Virology
- Full Member, International Society for Molecular Plant-Microbe Interactions
- Full Member, Canadian Society of Plant Physiologists
- Full Member, Canadian Phytopathological Society
Research Publications:
The links below lead to abstracts with access to full text.2013:
- Cui, H., Hong, N., Wang, G.P., and Wang, A.M. (2013). "Genomic segments RNA1 and RNA2 of Prunus necrotic ringspot virus codetermine viral pathogenicity to adapt to alternating natural Prunus hosts.", Molecular Plant-Microbe Interactions, 26(5), pp. 515-527. doi : 10.1094/MPMI-12-12-0282-R
- Elhiti, M., Hebelstrup, K.H., Wang, A.M., Li, C.L., Cui, Y., Hill, R.D., and Stasolla, C. (2013). "Function of type-2 Arabidopsis hemoglobin in the auxin-mediated formation of embryogenic cells during morphogenesis.", Plant Journal. doi : 10.1111/tpj.12181
- Wang, X., Kohalmi, S.E., Svircev, A.M., Wang, A.M., Sanfaçon, H., and Tian, L.-N. (2013). "Silencing of the Host Factor eIF(iso)4E Gene Confers Plum Pox Virus Resistance in Plum.", PLoS ONE, 8(1, Article No. e50627). doi : 10.1371/journal.pone.0050627
- Wei, T., Zhang, C., Hou, X., Sanfaçon, H., and Wang, A.M. (2013). "The SNARE protein Syp71 is essential for Turnip mosaic virus infection by mediating fusion of virus-induced vesicles with chloroplasts.", PLoS Pathogens, 9(5), pp. e1003378. doi : 10.1371/journal.ppat.1003378
- Xiong, R. and Wang, A.M. (2013). "SCE1, the SUMO-conjugating enzyme in plants that interacts with NIb, the RNA-dependent RNA polymerase of Turnip mosaic virus is required for viral infection.", Journal of Virology, 87(8), pp. 4704-4715. doi : 10.1128/JVI.02828-12
2012:
- Cui, H., Hong, N., Wang, G.P., and Wang, A.M. (2012). "Detection and genetic diversity of Prunus necrotic ringspot virus in the Niagara Fruit Belt, Canada.", Canadian Journal of Plant Pathology / Revue canadienne de phytopathologie, 34(1), pp. 104-113. doi : 10.1080/07060661.2012.661768
- Cui, H., Hong, N., Wang, G.P., and Wang, A.M. (2012). "Molecular characterization of two prunus necrotic ringspot virus isolates from Canada.", Archives of Virology, 157(5), pp. 999-1001. doi : 10.1007/s00705-1247-5
- Tang, X., Bian, S., Tang, M., Lu, Q.S., Li, S., Liu, X., Tian, G., Nguyen, V., Tsang, E.W.T., Wang, A.M., Rothstein, S.J., Chen, X., and Cui, Y. (2012). "MicroRNA-Mediated Repression of the Seed Maturation Program during Vegetative Development in Arabidopsis.", PloS Genetics, 8(11, Article No. e1003091). doi : 10.1371/journal.pgen.1003091
- Tang, X., Lim, M.-H., Pelletier, J., Tang, M., Nguyen, V., Keller, W.A., Tsang, E.W.T., Wang, A.M., Rothstein, S.J., Harada, J.J., and Cui, Y. (2012). "Synergistic repression of the embryonic programme by SET DOMAIN GROUP 8 and EMBRYONIC FLOWER 2 in Arabidopsis seedlings.", Journal of Experimental Botany, 63(3), pp. 1391-1404. doi : 10.1093/jxb/err383
- Wang, A.M. and Krishnaswamy, S. (2012). "Eukaryotic translation initiation factor 4E-mediated recessive resistance to plant viruses and its utility in crop improvement.", Molecular Plant Pathology, 13(7), pp. 795-803. doi : 10.111/j.1364-3703.2012.00791.X
- Zhang, L.R. and Wang, A.M. (2012). "Virus-induced ER stress and the unfolded protein response.", Frontiers in Plant Science, 3(293), pp. 1-16. doi : 10.3389/fpls.2012.00293
2011:
- Chowda-Reddy, R.V., Sun, H., Chen, H., Poysa, V., Ling, H., Gijzen, M., and Wang, A.M. (2011). "Mutations in the P3 Protein of Soybean mosaic virus G2 Isolates Determine Virulence on Rsv4-Genotype Soybean.", Molecular Plant-Microbe Interactions, 24(1), pp. 37-43. doi : 10.1094/MPMI-07-10-0158
- Chowda-Reddy, R.V., Sun, H., Poysa, V., and Wang, A.M. (2011). "Simultaneous Mutations in Multi-Viral Proteins Are Required for Soybean mosaic virus to Gain Virulence on Soybean Genotypes Carrying Different R Genes.", PLoS ONE, 6(11, Article No. e28342). doi : 10.1371/journal.pone.0028342
- Wang, A.M., Wang, D.J., Chowda-Reddy, R.V., Chen, H., and Ma, S. (2011). "Development of a Plant-based Vaccine against Porcine reproductive and respiratory syndrome virus:Research Progress and Future Prospects.", The Americas Journal of Plant Science and Biotechnology, 5(Spec. Issue 1), pp. 127-131.
2010:
- Babu, M.R., Griffiths, J.S., and Wang, A.M. (2010). "Isolation and transfection of plant protoplasts for studying infection and replication of plant viruses.", in Wang, A. (ed.) - Principles and Practice of Advanced Technology in Plant Virology, Research Signpost, Kerala, India, Chapter 8, pp. 141-152.
- Collins, A.M., Rehman, M.M., Chowda-Reddy, R.V., Wang, A.M., Fondong, V.N., Brown, J., and Roye, M.E. (2010). "Molecular characterization and experimental host range of an isolate of Macroptilium golden mosaic virus that infects Wissadula amplissima in Jamaica.", Virus Research, 150, pp. 148-152. doi : 10.1016/j.virusres.2010.03.008
- Cui, X., Wei, T., Chowda-Reddy, R.V., Sun, G., and Wang, A.M. (2010). "The Tobacco etch virus P3 protein forms mobile inclusions via the early secretory pathway and traffics along actin microfilaments.", Virology, 397(1), pp. 56-63. doi : 10.1016/j.virol.2009.11.015
- Huang, T.-S., Wei, T., Laliberte, J-F., and Wang, A.M. (2010). "A Host RNA Helicase-Like Protein, AtRH8, Interacts with the Potyviral Genome-Linked Protein, VPg, Associates with the Virus Accumulation Complex, and Is Essential for Infection.", Plant Physiology, 152(1), pp. 255-266. doi : 10.1104/pp.109.147983
- Wang, A.M. (2010). "Viral vectors: A powerful platform technology for the expression of vaccine subunits, therapeutic peptides and industrial proteins in plants.", in Wang, A. (ed.) - Principles and Practice of Advanced Technology in Plant Virology, Research Signpost, Kerala, India, Chapter 19, pp. 331-347.
- Wang, A.M., Huang, T.-S., Cui, X., Yi, J., Cui, Y., and Brown, D.C.W. (2010). "Application of cDNA-AFLP, EST, and the yeast two-hybrid system in plant virus research.", in Wang, A. (ed.) - Principles and Practice of Advanced Technology in Plant Virology, Research Signpost, Kerala, India, Chapter 11, pp. 175-188.
- Wang, L.P., Hong, N., Wang, G.P., Xu, W.X., Michelutti, R., and Wang, A.M. (2010). "Distribution of apple stem grooving virus and apple chlorotic leaf spot virus in infected in vitro pear shoots.", Crop Protection, 29(12), pp. 1447-1451. doi : 10.1016/j.cropro.2010.08.003
- Wei, T., Huang, T.-S., McNeil, J.R., Laliberte, J-F., Hong, J., Nelson, R.S., and Wang, A.M. (2010). "Sequential recruitment of the endoplasmic reticulum and chloroplasts for plant potyvirus replication.", Journal of Virology, 84(2), pp. 799-809. doi : 10.1128/JVI.01824-09
- Wei, T., Zhang, C., Hong, J., Xiong, R., Kasschau, K.D., Zhou, X., Carrington, J.C., and Wang, A.M. (2010). "Formation of Complexes at Plasmodesmata for Potyvirus Intercellular Movement Is Mediated by the Viral Protein P3N-PIPO.", PLoS Pathogens, 6(6, Article No. e1000962). doi : 10.1371/journal.ppat.1000962
2009:
- Collins, A.M., Mujaddad-ur-Rehman, M., Brown, J.K., Chowda-Reddy, R.V., Wang, A.M., Fondong, V.N., and Roye, M.E. (2009). "Molecular characterization and experimental host range of an isolate of Wissadula golden mosaic St. Thomas virus.", Virus Genes, 39(3), pp. 387-395. doi : 10.1007/s11262-009-0401-y
- Cotton, S., Grangeon, R., Thivierge, K., Mathieu, I., Ide, C., Wei, T., Wang, A.M., and Laliberte, J-F. (2009). "Turnip Mosaic Virus RNA Replication Complex Vesicles Are Mobile, Align with Microfilaments, and Are Each Derived from a Single Viral Genome.", Journal of Virology, 83(20), pp. 10460-10471. doi : 10.1128/JVI.00819-09
- Viel, C., Ide, C., Cui, X., Wang, A.M., Farsi, M., Michelutti, R., and Strömvik, M.V. (2009). "Isolation, partial sequencing, and phylogenetic analyses of Soybean mosaic virus (SMV) in Ontario and Quebec.", Canadian Journal of Plant Pathology / Revue canadienne de phytopathologie, 31(2), pp. 108-113. doi : 10.1080/07060660909507579
- Wang, A.M., Tian, L.-N., Huang, T.-S., Brown, D.C.W., Svircev, A.M., Stobbs, L.W., Miki, B.L.A., and Sanfaçon, H. (2009). "The development of genetic resistance to plum pox virus in transgenic Nicotiana benthamiana and Prunus domesticus.", Acta Horticulturae (ISHS), 839, pp. 665-672.
Other Science Related Publications:
2012:
- Brown, D.C.W. and Wang, A.M. (2012). "Recent Progress in Developing genetic Resistance against Plum Pox Virus.", Canadian Phytopathological Society (CPS) 83rd Annual Meeting and International PPV Meeting, Marriott Gateway On The Falls, Niagara Falls, ON, Canada, June 24-27, 2012.
- Cui, H. and Wang, A.M. (2012). "Virus against virus: development of a prunus necrotic ringspot virus-based vector against plum pox virus.", 31st Annual Meeting of American Society for Virology, University of Wisconsin-Madison, Madison, WI, USA, July 21-25, 2012. (Presentation)
- Li, Y., Bernards, M.A., and Wang, A.M. (2012). "Molecular identification and characterization of Aeabidopsis DEAD box RNA helicases associated with turnip mosaic virus infection.", 31st Annual Meeting of American Society for Virology, University of Wisconsin-Madison, Madison, WI, USA, July 21-25, 2012. (Presentation)
- Ma, S. and Wang, A.M. (2012). "Molecular Farming in Plants: An Overview.", in Wang, A. and Ma, S. (eds.) - Molecular Farming in Plants: Recent Advances and Future Prospects, Springer, Chapter 1, pp. 1-20.
- Tian, L.-N., Wang, X., Kohalmi, S.E., Svircev, A.M., Wang, A.M., Sanfaçon, H., Brown, D.C.W., and Schneider, K.E. (2012). "Control of the expression of the host factor eIF(iso)4E gene for Plum Pox Virus resistance.", Joint Canadian Phytopathological Society (CPS) 83rd Annual Meeting and International PPV Meeting, Marriott Gateway On The Falls, Niagara Falls, ON, Canada, June 24-27, 2012. (Presentation)
- Wang, A.M. (2012). "Developing Genetic Resistance to Fruit Tree Viruses via Advanced Biotechnology.", Ontario Tender Fruit Producers Annual General Meeting, Hernder Estates Winery, St. Catharines, ON, March 28, 2012. (Presentation)
- Wang, A.M. (2012). "Developing Genetic Resistance to Plant Viruses via Advanced Biotechnology.", Fuji Academy of Agricutlural Sciences, Fuzhou, China, October 29, 2012. (Presentation)
- Wang, A.M. (2012). "Developing Genetic Resistance to Plant Viruses via Advanced Biotechnology.", Jiangsu Academy of Agricultural Sciences, Nanjing, China, November 5, 2012. (Presentation)
- Wang, A.M. (2012). "Molecular Understanding of Plant Potyviruses.", Nanjing Agricultural University, Nanjing, China, November 6, 2012. (Presentation)
- Wang, A.M. (2012). "Plant Virus-Mediated Expression in Molecular Farming.", in Wang, A. and Ma, S. (eds.) - Molecular Farming in Plants: Recent Advances and Future Prospects, Springer, Chapter 10, pp. 199-216.
- Wang, A.M. (2012). "Towards Developing Novel Strategies against Plant Potyviruses.", Seminar, INRA, Bordeaux, Canada, March 6, 2012. (Presentation)
- Wang, A.M. (2012). "Understanding and control of plant potyviruses.", 50th anniversary celebration of the Korean Society of Plant Pathology, Seoul, South Korea, October 24-26, 2012.
- Wang, A.M. and Ma, S. (2012). "Preface.", in Wang, A. and Ma, S. (eds.) - Molecular Farming in Plants: Recent Advances and Future Prospects, Springer, pp. v-vi.
- Wang, A.M. and Ma, S. (Eds.) (2012). Molecular Farming in Plants: Recent Advances and Future Prospects., Springer. (Book)
- Wang, A.M. and Xiong, R. (2012). "Post-translational modification of the potyviral RNA-dependent RNA polymerase by Arabidopsis SUMO3.", 31st Annual Meeting of American Society for Virology, University of Wisconsin-Madison, Madison, WI, USA, July 21-25, 2012.
2011:
- Chowda-Reddy, R.V. and Wang, A.M. (2011). "Molecular interactions between soybean genotypes and SMV.", Annual Ontario Oil and Protein Seed Crop Committee (OOPSCC) and Ontario Soybean Growers’s Research Meeting, London, ON, Canada, June 28, 2011. (Presentation)
- Chowda-Reddy, R.V., Sun, S., Wang, A.M., and Poysa, V. (2011). Soybean mosaic virus isolate Rsv4-RB3, complete genome sequence. GenBank accession #: JN416770.
- Cui, H. and Wang, A.M. (2011). "Virus against virus: Development of a Prunus necrotic ringspot virus-based vector against Plum pox virus.", 8th Canadian Plant Genomics Workshop, Niagara Falls, ON, Canada, August 22-25, 2011. (Poster)
- Li, Y., Chowda-Reddy, R.V., Bernards, M.A., and Wang, A.M. (2011). "Molecular identification of host membrane-associated proteins that interact with the potyviral P3 protein.", 29th Annual Meeting of American Society for Virology, Montana State University, Bozeman, MT, USA, July 17-21, 2010. (Poster)
- Pan, Q., Bernards, M.A., and Wang, A.M. (2011). "Molecular characterization of the first protein of tobacco etch virus.", 8th Canadian Plant Genomics Workshop, Niagara Falls, ON, Canada, August 22-25, 2011. (Poster)
- Wang, A.M. (2011). "Understanding and control of plant potyviruses.", Journal of Antivirals & Antiretrovirals, 3(4), pp. 179. (Abstract)
- Wang, A.M. (2011). "Understanding and control of plant potyviruses.", International conference and exhibition on virology, Baltimore, MD, USA, September 5-7, 2011. (Presentation)
- Wang, A.M. (2011). "Understanding and control of plant viruses.", Canadian Phytopathological Society (CPS) South Western Ontario Regional 2011 Meeting, London, ON, Canada, November 5, 2011.
- Wang, A.M. and Cui, H. (2011). "Development of a Prunus necrotic ringspot virus-based viral vector for characterization of gene functions and control of viral diseases in stone fruits.", Canadian Phytopathological Society (CPS) South Western Ontario Regional 2011 Meeting, London, ON, Canada, November 5, 2011. (Poster)
- Wang, A.M., Chen, X., and Cui, X. (2011). "Detection, Understanding and Control of Soybean Mosaic Virus.", in Sudaric, A. (ed.) - Soybean - Molecular Aspects of Breeding, InTech, Open Access Publisher, Chapter 15, pp. 335-354.
- Xiong, R. and Wang, A.M. (2011). "The potyviral RNA-dependent RNA polymerase is a potential SUMO susbtarcte in Planta.", 30th Annual Meeting of American Society for Virology, University of Minnesota, Minneapolis, MN, USA, July 16-20, 2011. (Poster)
2010:
- Chowda-Reddy, R.V. and Wang, A.M. (2010). Complete cDNA sequence of SMV isolate NP-C-L. GenBank HQ166265.
- Chowda-Reddy, R.V. and Wang, A.M. (2010). Complete cDNA sequence of SMV isolate NP-L. GenBank HQ166266.
- Chowda-Reddy, R.V., Sun, S., and Wang, A.M. (2010). "A single positively charged amino acid substitution in the C-terminal region of the Soybean mosaic virus P3 protein is responsible for breaking Rsv4 resistance in soybean.", Plant Biology 2010: Joint meeting of the Canadian Society of Plant Physiologists (CSPP) and American Society of Plant Biologists (ASPB), Montréal Convention Centre, Montréal, QC, Canada, July 31-August 4, 2010. (Poster)
- Wang, A.M. (2010). "Preface.", in Wang, A. (ed.) - Principles and Practice of Advanced Technology in Plant Virology, Research Signpost, Kerala, India.
- Wang, A.M. (2010). "Soybean mosaic virus in Canada and its control strategy.", OOPSCC/OSG Annual Meeting, Ottawa, ON, Canada, June 24, 2010. (Presentation)
- Wang, A.M. (Ed.) (2010). Principles and practice of advanced methods in plant virology., Research Signpost, Kerala, India. (Book)
- Wang, A.M. and Wei, T. (2010). "Sequential recruitment of the endoplasmic reticulum and chloroplasts for plant potyvirus replication.", 29th Annual Meeting of American Society for Virology, Montana State University, Bozeman, MT, USA, July 17-21, 2010.
2009:
- Chen, X., Li, X.-Z., Wang, A.M., and Zhou, T. (2009). "Induced resistance against Monilinia fructicola on peaches elicited by Bacillus sp. BMO1.", 14th International Congress on Molecular Plant-Microbe Interactions, Centre des congrès de Québec, Québec City, QC, Canada, July 19-23, 2009.
- Chowda-Reddy, R.V., Sun, S., and Wang, A.M. (2009). "Identification of genomic region responsible from Soybean mosiac virus-London resistance breaking (SMV-LRB) against Rsv4 resistance gene in V94-5152 soybean host.", 14th International Congress on Molecular Plant-Microbe Interactions, Centre des congrès de Québec, Québec City, QC, Canada, July 19-23, 2009.
- Cui, X. and Wang, A.M. (2009). "The molecular identification and characterization of host proteins associated with Soybean mosaic virus (SMV) infection.", Canadian Journal of Plant Pathology / Revue canadienne de phytopathologie, 31(1), pp. 151-152. (Abstract)
- Sun, S., Chowda-Reddy, R.V., and Wang, A.M. (2009). "Construction of a Soybean mosaic virus-based vector and assessment of its application for studying gene functions in soybean through virus induced gene silencing.", Canadian Phytopathological Society (CPS) South Western Ontario Regional 2009 Meeting, SCPFRC, AAFC, London, ON, Canada, November, 7, 2009, Published in : Canadian Journal of Plant Pathology, 32(3), pp. 428.
- Zhang, C., Li, Y., Bernards, M.A., and Wang, A.M. (2009). "Screening for translation initiation factors that are required for Turnip mosaic virus infection.", Canadian Phytopathological Society (CPS) South Western Ontario Regional 2009 Meeting, SCPFRC, AAFC, London, ON, Canada, November, 7, 2009, Published in : Canadian Journal of Plant Pathology, 32(3), pp. 428-429.