Sanfaçon, Hélène, Ph.D.

• Research Publications
• Other Science Related Publications

Contact Information:

4200 Hiaghway 97
PO Box 5000
Summerland, British Columbia V0H 1Z0
Telephone: 250-494-6393
Fax: 250-494-0755
Email: helene.sanfacon@agr.gc.ca

Areas of Expertise:

• molecular biology of plant viruses
• methodology development for plant virus resistance
• characterization of plant virus replication complexes
• characterization of host factors involved in virus replication
• study of viral proteases and design of inhibitors
• characterization of tomato ringspot virus
• development of genetic resistance to plum pox virus
• characterization of viruses infecting fruit trees and small fruits

Current Projects:

• Characterization of replication and translation complexes associated with plant RNA viruses (Sanfacon)
• Development of genetic resistance to Plum pox virus in Canada

Affiliations:

• Adjunct Professor, Dept. Botany, University of British Columbia
• Chair Comoviridae study group, International Committee for the Taxonomy of Viruses
• Associate Editor, Canadian Journal of Botany

Research Publications:

2013:

• Wang, X., Kohalmi, S.E., Svircev, A.M., Wang, A.M., Sanfaçon, H., and Tian, L.-N. (2013). "Silencing of the Host Factor eIF(iso)4E Gene Confers Plum Pox Virus Resistance in Plum.", PLoS ONE, 8(1, Article No. e50627). doi : 10.1371/journal.pone.0050627
• Wei, T., Zhang, C., Hou, X., Sanfaçon, H., and Wang, A.M. (2013). "The SNARE protein Syp71 is essential for Turnip mosaic virus infection by mediating fusion of virus-induced vesicles with chloroplasts.", PLoS Pathogens, 9(5), pp. e1003378. doi : 10.1371/journal.ppat.1003378

2011:

• Jovel, J., Walker, M.C., and Sanfaçon, H. (2011). "Salicylic acid-dependent restriction of tomato ringspot virus spread in tobacco is accompanied with a hypersensitive response, local RNA silencing and moderate systemic resistance.", Molecular Plant-Microbe Interactions, 24(6), pp. 706-718. doi : 10.1094/MPMI-09-10-0224

2010:

• Laliberte, J-F. and Sanfaçon, H. (2010). "Cellular remodeling during plant virus infection.", Annual Review of Phytopathology, 48, pp. 69-91. doi : 10.1146/annurev-phyto-073009-114239
• Tian, L.-N., Svircev, A.M., Sanfaçon, H., Brown, D.C.W., Schneider, K.E., Sibbald, S., and Malutan, T. (2010). "Development of Plum pox virus resistance in plum via expression of an intron-spliced hairpin HC-Pro transgene.", Genes, Genomes & Genomics, 4(Suppl. 1), pp. 28-31.

2009:

• Jafarpour, B. and Sanfaçon, H. (2009). "Insertion of large amino acid repeats and point mutations contribute to a high degree of sequence diversity in the X4 protein of tomato ringspot virus (genus Nepovirus).", Archives of Virology, 154(10), pp. 1713-1717. doi : 10.1007/s00705-009-0497-3
• Sanfaçon, H. (2009). "Secoviridae: the amalgamation of the family Comoviridae and Sequiviridae.", Encyclopedia of Life Sciences, eLS. doi : 10.1002/9780470015902.a0000764.pub2
• Sanfaçon, H., Wellink, J., Le Gall, O., Karasev, A.V., van der Vlugt, R., and Wetzel, T. (2009). "Secoviridae: a proposed family of plant viruses within the order Picornavirales that combines the families Sequiviridae and Comoviridae, the unassigned genera Cheravirus and Sadwavirus, and the proposed genus Torradovirus.", Archives of Virology, 154(5), pp. 899-907. doi : 10.1007/s00705-009-0367-z
• Wang, A.M., Tian, L.-N., Huang, T.-S., Brown, D.C.W., Svircev, A.M., Stobbs, L.W., Miki, B.L.A., and Sanfaçon, H. (2009). "The development of genetic resistance to plum pox virus in transgenic Nicotiana benthamiana and Prunus domesticus.", Acta Horticulturae (ISHS), 839, pp. 665-672.

Other Science Related Publications:

2013:

• Ghoshal, B. and Sanfaçon, H. (2013). "Symptom recovery in Nicotiana benthamiana plants infected with tomato ringspot virus is associated with Argonaute 1-dependent translational repression of the viral genome.", Keystone Symposium on RNA Silencing, Whistler Conference Centre, Whistler, BC, Canada, March 19-24 2013. (Poster)

2012:

• Sanfaçon, H., Walker, M.C., Jovel, J., Karran, R., Ghoshal, B., Chisholm, J., and Wei, T. (2012). "In depth study of the interaction of peach viruses with plant defense responses for improved management of PPV.", Joint Canadian Phytopathological Society (CPS) 83rd Annual Meeting and International PPV Meeting, Marriott Gateway On The Falls, Niagara Falls, ON, Canada, June 24-27, 2012. (Presentation)
• Tian, L.-N., Wang, X., Kohalmi, S.E., Svircev, A.M., Wang, A.M., Sanfaçon, H., Brown, D.C.W., and Schneider, K.E. (2012). "Control of the expression of the host factor eIF(iso)4E gene for Plum Pox Virus resistance.", Joint Canadian Phytopathological Society (CPS) 83rd Annual Meeting and International PPV Meeting, Marriott Gateway On The Falls, Niagara Falls, ON, Canada, June 24-27, 2012. (Presentation)
• Wei, T., Chisholm, J., and Sanfaçon, H. (2012). "Stability of the tomato ringspot virus RNA-dependent RNA polymerase in plants: exploring possible interactions with components of the proteaseome and with caspase-like proteases.", XV International Congress of Virology, Sapporo, Japan, September 11-16, 2011. (Abstract)

2011:

• Ghoshal, B. and Sanfaçon, H. (2011). "Accumulation of viral products during the symptomatic and recovery phase in Nicotiana benthamiana plants infected with tomato ringspot virus isolates differing in their virulence.", XV International Congress of Virology, Sapporo, Japan, September 11-16, 2011. (Presentation)
• Sanfaçon, H. and Fuchs, M. (2011). "Tomato ringspot virus.", in Hadidi, A., Barba, M., Candresse, T., and Jelkmann, W. (eds.) - Virus and Virus-Like Diseases of Pome and Stone Fruits, American Phytopathological Society (APS), Chapter 9, Part II. Pome Fruit Viruses and Related Diseases.
• Sanfaçon, H., Gorbalenya, A.E., Knowles, N.J., and Chen, Y. (2011). "Order Picornavirales.", in King, A.M.Q., Adams, M.J., Carstens, E.B. and Lefkowitz, E.J. - Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Elsevier, pp. 835-839.
• Sanfaçon, H., Iwanami, T., Karasev, A.V., van der Vlugt, R., Wellink, J., Wetzel, T., and Yoshikawa, N. (2011). "Family Secoviridae.", in King, A.M.Q., Adams, M.J., Carstens, E.B. and Lefkowitz, E.J. - Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Elsevier, pp. 881-899.
• Wei, T., Chisholm, J., and Sanfaçon, H. (2011). "Sequence analysis of RNA1-encoded replication proteins of tomato ringspot nepovirus isolates.", XV International Congress of Virology, Sapporo, Japan, September 11-16, 2011. (Poster)

2010:

• Sanfaçon, H. (2010). "Emerging technologies for the control of plant virus diseases.", in Wang, A. (ed.) - Principles and Practice of Advanced Technology in Plant Virology, Research Signpost, Kerala, India, Chapter 17, pp. 295-310.
• Tian, L.-N., Svircev, A.M., Sanfaçon, H., and Brown, D.C.W. (2010). "Plum pox virus resistance stability and expression of specific siRNAs in plum.", US/Canada Plum Pox Virus Update and International Research Symposium, Kearneysville, WV, USA, January 4-6, 2010.

2009:

• Le Gall, O., Sanfaçon, H., Ikegami, M., Iwanami, T., Jones, T., Karasev, A.V., Lehto, K., Wellink, J., Wetzel, T., and Yoshikawa, N. (2009). "Cheravirus and Sadwavirus: Two unassigned genera of plant positive-sense single-stranded RNA viruses formerly considered atypical members of the genus Nepovirus (family Comoviridae) [Archives of Virology 152(9), pp.1767-1774] (Erratum).", Archives of Virology, 154(6), pp. 1019.